Chelsea present the most difficult test yet of United's recent upturn in form, with a record of one defeat in their last 28 games in all competitions going up against the runaway league leaders in the last of this season's FA Cup quarter-finals.
It is quite the absentee list which Jose Mourinho is having to wrestle with as he takes his Manchester United team to Stamford Bridge on Monday night.
Marouane Fellaini repaid Jose Mourinho's faith with a late header that gave Manchester United a 2-0 EFL Cup semi-final advantage against injury-ravaged Hull.
The Belgium midfielder has long been a divisive figure at Old Trafford and has even been jeered by pockets of home fans recently.
The Ivorian has impressed under Mourinho and his presence in United's backline has been sorely missed.
However, Fellaini has been continually backed by Mourinho and ended Tuesday's first-leg encounter with the Stretford End chanting his name after he nodded home a late goal to add to Juan Mata's close-range opener.
It was a late sucker-punch for a Hull side forced to play two midfielders in defence due to injury problems that worsened as Markus Henriksen and Josh Tymon were forced off in their first ever EFL Cup semi-final appearance.
Moreover, the under-23 side have also been playing without a recognised striker for a period of some months, meaning there can be no Rashford-esque impact player thrown into the mix. He will have to shuffle his pack somehow, using whatever is available in his first-team squad to plug the gap.
But that is not to say he doesn't have options.
But Hull played surprisingly well and Harry Maguire soon went on a run that belied his role as hulking defender, bursting from his own half and showing some nice touches before getting a shot at David de Gea.